Benign fibro osseous condition involving one or more bones of the cranial and extracranial skeleton, consists of nonencapsulated lesions which show replacement of normal bone by cellular fibrous tissues edwards 1984 originally introduced by lichtenstein in 1938 one of the most perplexing diseases of osseous tissues. Looking for online definition of fibroosseous, lesion jaw in the medical dictionary. With the exception of fibrous dysplasia, the remaining true fibro osseous lesions to be described are unique to the jaws. Fibro osseous lesions fols are a generic designation of poorly defined group of lesions which are recognized to affect the jaws and the.
Two previous reports have designated similar tumors as fibroosseous lesions. Fibroosseous, lesion jaw definition of fibroosseous. The clinical, radiographic, and pathologic features of five cases are presented, and this uncommon. Fibroosseous lesions of the maxillas the present study examines the principal characteristics of 11 benign fibroosseous lesions of the maxillas spe. Mdm2 and cdk4 immunohistochemistry is a valuable tool in. J dent oral health fibroma is a benign tumor of connective tissue origin, which is. Fibroosseous lesions of the face and jaws sciencedirect. Fibro osseous lesions are a heterogeneous group of benign lesions of unknown aetiology affecting the jaws and other craniofacial bones. Figure 2 bone fibroosseous lesion in a female b6c3f1n mouse from a chronic study. Veterinary pathology benign and malignant proliferative. During the last decade much has changed in our understanding of fibroosseous lesions fols of the jaws with regards to their imaging, their nomenclature and classification, and their potential. The benign fibroosseous lesions of the jaws and craniofacial complex encompass a diverse group of diseases with quite variable aetiologies and pathogenesis but which share similar and overlapping histological features that can make precise categorization difficult. The fibroosseous lesions may actually represent distinct phases of a single benign morphological process. Sometimes, the classic clinical, radiologic or pathologic.
Fibroosseous lesions of the craniofacial complex comprise of a diverse, interesting and challenging group of conditions that pose difficulties in classification and treatment. The most important lesions in the differential diagnosis are osteoblastoma and giant cell reparative granuloma. Fibroosseous lesions of the face and jaws request pdf. The benign fibroosseous lesions bfol are characterized by. Fibrous dysplasia may present with painless facial swelling and asymmetry.
The benign fibroosseous lesions bfol represent a clinically diverse group of disorders of bone that share similar histopathologic features. Clinical, radiographic, biochemical and histological findings of florid cementoosseous dysplasia and report of a case. Advances in diagnosis and management of fibroosseous lesions. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Aneurysmal bone cyst engraftment on benign fibroosseous lesions, well known to occur in the extracranial skeleton, has been reported infrequently in the craniofacial bones. Fibroosseous lesions fol are a group of lesions which are known to affect the jaws and the craniofacial bones which is regarded as very confusing. A rare tumor closely associated with the trigeminal ganglion produced a syndrome of atypical facial pain in a 44yearold man. Benign fibroosseous lesions of the craniofacial complex. This fibro osseous lesion shows replacement of bone by fibrovascular tissue. Benign fibroosseous lesions is a group of lesions in which normal bone is replaced initially by fibrous connective tissue and over a period of time, the lesion is infiltrated by osteoid and cementoid tissue.
Nonneoplastic, calcified, fibroosseous lesions known as calcifying pseudoneoplasms of the neuraxis capnon are rare and can occur anywhere within the neuraxis. However, these lesions also arise in ovariectomized female mice and castrated males. Fibro osseous lesions, pathophysiology, radiography he term fibro osseous lesions fols is a generic designation of poorly defined group of lesions affecting the jaws and cranio facial bones. All are characterized by the replacement of bone by cellular. Diagnosing the most common odontogenic cystic and osseous. Maxillofacial fibroosseous lesions clinical radiology. Fibroosseous lesions the term fibroosseous lesion fol is a generic designation of a group of jaw disorders characterized by the replacement of bone by a benign connective tissue matrix.
Whereas some are diagnosable histologically, most require a combined assessment of clinical, microscopic and radiologic features. Pdf fibro osseous lesions fols are a generic designation of poorly defined group of lesions which are recognized to affect the jaws and the. Fibroosseous lesions of the head and neck diagnostic. Fibrous dysplasia and juvenile ossifying fibroma are variants in a spectrum of histologically similar but biologically diverse fibroosseous lesions that affect the craniofacial bones the group also includes cementifying fibroma. After histological verification of the fibroosseous nature of the process, 5 lesions were diagnosed on a radiological basis as fibrous dysplasia exhibiting diffuse blending margins, while the diagnosis of ossifying fibroma was given to 10 radiologically sharplydemarcated lesions. When this combined lesion occurs in the skull the clinical and radiographic features often suggest an aggressive neoplasm. From the archives of the afip pediatric orbit tumors and. Fibroosseous cemental lesions presum ably arising in the periodontal ligament. Figure 4 bone fibroosseous lesion in a female b6c3f1n mouse from a chronic study. Historically, fol has been referred to by a variety of names, including fibroosseous dysplasia, fibrous dysplasia, focal osteodystrophy, osteodysplasia, osteofibrosis, and osteodystrophy, but the preferred term for these lesions is fibroosseous lesion. Benign fibroosseous lesions of the craniofacial complex a.
Nasal cavity, paranasal sinuses, nasopharynx fibroosseous lesions. Eversole fibro osseous lesions are a diverse group of processes that are characterized by. Figure 3 bone fibroosseous lesion in a female b6c3f1n mouse from a chronic study. Fibroosseous lesions of the maxillas med oral patol oral cir bucal. Fibroosseous lesions introduction the term fol is a generic designation of a group of bone disorders characterized by the replacement of bone by a benign. Vuhahula3, karpal singh sohal2, 1 department of oral and maxillofacial surgery, mbabane government hospital, mbabane, swaziland 2 department of oral and maxillofacial surgery, muhimbili university of health and allied sciences, dar. These lesions represent a clinical spectrum ranging from very innocent lesions requiring no treatment at all to very aggressive and malignant neoplasms. Maxillofacial fibroosseous lesions fol consists of lesions that differ, with the exception of fibrous dysplasia, to those found in the rest of the skeleton.
As a group, they are relatively common in the craniofacial complex, especially the jaws. Jonathan swift 1667 1745 benign fibroosseous lesions. This chapter demonstrates the variation in the radiological appearances of conditions of fibro. Other cementoosseous dysplasias defined as lesions which share some of the. Bone fibroosseous lesion nonneoplastic lesion atlas. The radiologic and histopathologic characteristics of this unusual entity are not well understood.
Fibroosseous lesion is a generic designation for a clinically diverse group of bone disorders in which the lesional tissue consists of large volumes of fibrous connective tissue, principally collagens type i and iii, as well as an osseous component in the form of woven or lamellar bone or cementum with varying degrees of mineralization. Of and fibrous dysplasia are very similar microscopically, and thus radiographic evaluation is essential in the interpretation of fibroosseous lesions. The purpose of this paper is to present an overview of the imaging features of the most prevalent benign bone tumors involving the spine. A bone biopsy, by the appropriate surgical specialist, should be obtained to confirm the. It cannot be over emphasized that in the case of fibroosseous lesions of. Benign fibroosseous lesions bfol of the jaw, facial and skull bones are a variant group of intraosseous disease processes that share microscopic features 14.
Pdf fibro osseous lesions classifications, pathophysiology. In this video we will wrap everything up by talking about oral pathology lesions that affect the jaw bones, and first up are fibroosseous lesions. These lesions exhibit nearly identical histomorphologic features, yet demonstrate widely ranging clinical behavior. This matrix displays varying degrees of mineralization in the form of woven bone or of cementumlike round. Fibroosseous lesions refer to a collection of nonneoplastic intraosseous lesions that replace normal bone and consist of a cellular fibrous connective tissue within which nonfunctional osseous structures form. Fols of the face and jaws are cementoossifying dysplasia, fibrous dysplasia and cementoossifying fibroma. Bone fibroosseous lesion national toxicology program. Lesions in this category include fibrous libyan j med, aop. Cementoosseous dysplasia cod is a benign fibroosseous lesion of bone, in which normal bone is replaced by fibrous tissue, followed by calcification with osseous and cementumlike tissue. Fibroosseous lesions of the craniofacial bones the. Levin et al24 and nishimura et al25 reported familial occurrence of fibroosseous dysplastic lesions of the jaw associated with osteogenesis imperfecta.
Histological appearance of fcod showed large sheets or fused globules of cementoosseous tissue, which may be fused to the roots of one or more teeth or may lay separately. Cementoosseous dysplasiacod is the most common fibroosseous lesion faced in clinical practice and affects the toothbearing areas of the jaws. Figure 1 bone fibroosseous lesion in the femur of a female b6c3f1n mouse from a chronic study. Fibro osseous lesions fols are a generic designation of poorly defined group of lesions which are recognized to affect the jaws and the craniofacial bones which are known for their confusing area in diagnostic pathology. Fibroosseous lesions fols arise commonly within the sternebrae, vertebrae. In the first volume of the journal of oral surgery, dr g.
The two most confused benign fibro osseous lesions are fibrous dysplasia and ossifying fibroma. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. Pressure from a denture may cause perforation of the overlying mucosa, exposing the lesion to the oral environment. There is replacement of bony trabeculae and the marrow cavity with fibrovascular stroma. Updated classification schemes for fibroosseous lesions of the.
Florid cementoosseous dysplasia large lesions may expand the cortices may be associated with simple bone cysts lesions with sbcs may produce a dull pain may become infected as surrounding bone resorbs. All of these conditions have a common denominator, which is the fibroblast cell. Ppt fibroosseous lesions powerpoint presentation free. When polyostotic fibroosseous lesions typical for fibrous dysplasia are associated with other anomalies and en docrinopathy, this variant form. Benign tumors of the osseous spine account approximately for 1% of all primary skeletal tumors. Fibrogenic, fibroosseous, and fibrohistiocytic lesions. Cbct findings of periapical cementoosseous dysplasia. During the last decade much has changed in our understanding of fibroosseous lesions fols of the jaws with regards to their imaging, their nomenclature and. Summary this chapter demonstrates the variation in the radiological appearances of conditions of fibro. Fibroosseous lesions of the maxillofacial bones should be classified based on their radiographic growth pattern. Fibrous dysplasia and ossifying fibroma an advent in. A free powerpoint ppt presentation displayed as a flash slide show on id. Fibroosseous lesions of the jaw and face must be differentiated from other bone lesions which may mimic them histologically and radiographically. Open access research article fibroosseous lesions of.